PRATHER Randall S.,WELLS Kevin D.,WHITWORTH Kristin M.
申请号：
SI201231423
公开号：
SI2709445T1
申请日:
2012.05.16
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
The disclosure relates to a genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles of a CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
