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PYRIPYROPENE DERIVATIVES HAVING ACAT2 INHIBITING ACTIVITY AND STABLE TO METABOLIZING ENZYMES
专利权人:
发明人:
申请号:
EP11762699.4
公开号:
EP2554546B1
申请日:
2011.03.25
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R 1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula -O-CH(R 7 )-R 8 where R 7 is a lower alkoxy group and R 8 is an aryl group, and R 2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a -CH 2 -acyloxy group and R 3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R 4 and R 3 is a group other than acetoxy, or R 2 and R 3 taken together form a group of the formula -O-CH(R 5 )-O- where R 5 is an aryl group.
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