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Pyripyropene derivative stable to metabolic enzymes showing ACAT2 inhibitory activity
专利权人:
学校法人北里研究所
发明人:
供田 洋,長光 亨,松田 大介,大城 太一,大多和 正樹,大村 智
申请号:
JP2012508258
公开号:
JP5592482B2
申请日:
2011.03.25
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R 1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula -O-CH(R 7 )-R 8 where R 7 is a lower alkoxy group and R 8 is an aryl group, and R 2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a -CH 2 -acyloxy group and R 3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R 4 and R 3 is a group other than acetoxy, or R 2 and R 3 taken together form a group of the formula -O-CH(R 5 )-O- where R 5 is an aryl group.
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