The present disclosure relates to a Wingless-type (wnt) inhibitor of formula (I) for use in the treatment of fibrosis and some fibrosis mediated disorders such as stiff skin syndrome and systemic sclerosis. The present disclosure also provides a method for the treatment of fibrosis, a pharmaceutical combination comprising a wnt inhibitor of formula (I) and a second active ingredient for use in the treatment of fibrosis and also the use of a wnt inhibitor of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of fibrosis and fibrosis mediated disorders..本發明係關於式(I)之Wingless型(wnt)抑制劑，其係用於治療纖維化及一些由纖維化介導之病症(諸如僵直皮膚症候群及全身性硬化症)。本發明亦提供一種用於治療纖維化之方法、用於治療纖維化之包含式(I)之wnt抑制劑及第二活性成分之醫藥組合亦及一種以式(I)之wnt抑制劑或其醫藥上可接受之鹽於製造用於治療纖維化及由纖維化介導之病症之藥物之用途。
