The invention relates to an orally administrable chewable pharmaceutical composition in unit dosage form comprising an oil-in-water emulsion in which the aqueous phase is gelled and in which the oil phase comprises a physiologically tolerable unsaturated fatty acid ester, wherein the aqueous phase comprises a physiologically active agent, or the oil phase comprises a physiologically tolerable lipid soluble material which is physiologically active. The invention also relates to such compositions for use in a method of treatment of a human by oral administration. The invention also relates to the use of a physiologically active agent or physiologically tolerable lipid soluble material for the preparation of a medicament for the treatment of a human by oral administration wherein said medicament is in the form of a composition according to the invention.