The present invention relates to spiro-isoquinoline-1,4'-piperidine compounds having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.本發明涉及具有針對西格瑪(σ)受體和μ-類鴉片受體兩者的雙藥理學活性之螺-異喹啉-1,4’-哌啶化合物，涉及製備這樣的化合物的方法，涉及包含它們的藥物組成物，並且涉及它們在治療中之用途，特別是用於治療疼痛。
