PROBLEM TO BE SOLVED: To provide: a transdermal absorption sheet with which control of the dissolution rate and suppression of the drug diffusion can be achieved； and a method of manufacturing the same.SOLUTION: A transdermal absorption sheet 100 includes a sheet portion 116, a plurality of frustum portions 114 disposed on the sheet portion 116, and needle portions 112 disposed on the frustum portions 114. Each of the plurality of needle portions 112 has a first layer 120 including a drug, and a second layer 122 not including a drug. At least one needle portion 112 of the plurality of needle portions 112 includes an air bubble 124.COPYRIGHT: (C)2016,JPO&INPIT【課題】溶解速度の制御と薬剤の拡散の抑制を達成できる経皮吸収シートおよびその製造方法を提供する。【解決手段】経皮吸収シート１００は、シート部１１６と、シート部１１６の上に配置された複数の錐台部１１４と、錐台部１１４の上に配置されたニードル部１１２とを備え、複数のニードル部１１２の各々が薬剤を含む第１層１２０と薬剤を含まない第２層１２２とを含み、複数のニードル部１１２のうち少なくとも一つのニードル部１１２が気泡１２４を含んでいる。【選択図】図３
