PHILIP WILSON HOWARD,KHONDAKER MIRAZUR RAHMAN,DAVID EDWIN THURSTON,PETER WILLIAM TAYLOR
申请号：
MX2014013144
公开号：
MX2014013144A
申请日:
2013.04.30
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
A compound of formula (I) or a salt or solvate thereof, wherein the dotted double bond indicates the presence of a single or double bond between C2 and C3 R2 is selected from -H, -OH, =O, =CH2, -CN, -R, OR, halo, dihalo, =CHR, =CHRR, -O- SO2-R, CO2R and COR R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR, nitro, Me3Sn and halo where R and R are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups R10 and R11 either together form a double bond, or are selected from H and QRQ respectively, where Q is selected from O, S and NH and RQ is H or C1-7 alkyl or H and SOxM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation A is selected from (A1), (A2), (A3), (A4) or (A5) where X1 and Y1 are selected from: CH and NH CH and NMe N and NMe CH and S N and S N and O and CH and O, respectively X2 and Y2 are selected from: CH and NH CH and NMe N and NMe CH and S N and S N and O and CH and O, respectively Z1 is selected from O and S Z2 is selected from CH and N F is selected from a single bond and –(E-F1)m- each E is independently selected from a single bond, and –C(=O)-NH- each F1 is independently a C3-20 heteroarylene group m is 1, 2 or 3 G is selected from hydrogen, C1-4alkyl, -C(=O)-O-C1-4alkyl, -(CH2)n-C3-20 heterocycloalkyl, and –O-(CH2)n-C3-20 heterocycloalkyl group each n is 0-4 provided that A2 is not A2, where X1 and Y1 of A2 are selected from: CH and NMe COH and NMe CH and S N and NMe N and S, respectively and provided that A3 is not A3, where X2 and Y2 of A3 are selected from: CH and NMe COH and NMe CH and S N and NMe N and S, respectively B is either a single bond or (B1), where X and Y of B1 are selected from: CH and NMe COH and NMe CH and S N and NMe N and S, respectively and R1 is C1-4 alkyl.Un compuesto de fórmula (I) o una sal o solvato del mismo, donde el enlace doble punteado indica la presencia de un enlace sencillo o doble entre C2 y C3 R2 es seleccionado de -H, -OH, =O, =
