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Process for manufscturing conjugates of improved homogeneity
专利权人:
IMMUNOGEN INC.
发明人:
申请号:
IL22856513
公开号:
IL228565D0
申请日:
2013.09.29
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C. or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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