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INTESTINAL FXR AGONISM ENHANCES GLP-1 SIGNALING TO RESTORE PANCREATIC BETA CELL FUNCTIONS
专利权人:
Salk Institute for Biological Studies
发明人:
Sungsoon Fang,Eiji Yoshihara,Ruth T. Yu,Annette Atkins,Michael Downes,Ronald M. Evans
申请号:
US15697271
公开号:
US20180000768A1
申请日:
2017.09.06
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed are embodiments of a method of treating or preventing latent autoimmune diabetes of adults (LADA) in a subject. Such embodiments include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or farnesoid X receptor (FXR) agonist compounds, thereby activating FXR receptors in the intestines, and treating or preventing latent autoimmune diabetes of adults (LADA) in the subject.
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