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Fluid composition comprising biocompatible polymeric and oligomeric compositions
专利权人:
TOLMAR THERAPEUTICS; INC.
发明人:
NORTON, RICHARD L.
申请号:
ES09758745
公开号:
ES2535330T3
申请日:
2009.06.03
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A fluid composition comprising: a biodegradable thermoplastic polyester polymer that is at least substantially insoluble in body fluid; a terminal biocompatible protected oligomeric liquid; and a bioactive agent, a metabolite or a prodrug thereof, in which the terminal biocompatible protected oligomeric liquid is of formula I, II, III, IV or V: ** Formula ** in which: each R1 is, so independent, (C1-C12) alkyl or (C1-C12) alkylcarbonyl (C1-C12) alkyl; each R2 is, independently, (C1-C12) alkyl, carbonyl (C1-C12) alkyl or (C1-C12) alkyl ester; each R3 is independently alkylene (C1-C12); R4 is (C1-C12) alkylene, carbonyl (C1-C12) alkylcarbonyl or (C3-C12) cycloalkadiyl; R5 is alcatriyl (C1-C12) or cycloalcatriyl (C3-C12); R6 is (C1-C12) alkylene, (C1-C12) alkyne, cycloalcadiyl (C3-C12), alktriyl (C1-C12) or cycloalcatriyl (C3-C12); R7 is (C1-C12) alkylene or (C1-C12) alktriyl, X is absent or is oxygen; W is absent, or is carbonyl or carbonyloxy; and any alkyl or alkylene of R1, R2, R3, R4, R5, R6 and R7 may optionally be substituted on the carbon with one or more oxo, halogen, nitro, cyano, (C1-C12) alkyl, (C1-C6 alkoxy) ), trifluoromethyl, and be optionally interrupted in the carbon with one or more oxy, imino or thio, and be optionally partially unsaturated; and each a, b, c and d is, independently, 0, 1, 2, 3, 4 or 5.Una composición fluida que comprende: un polímero de poliéster termoplástico biodegradable que es al menos sustancialmente insoluble en fluido corporal; un líquido oligomérico protegido terminalmente biocompatible; y un agente bioactivo, un metabolito o un profármaco del mismo, en la que el líquido oligomérico protegido terminalmente biocompatible es de fórmula I, II, III, IV o V:**Fórmula** en las que: cada R1 es, de manera independiente, alquilo (C1-C12) o alquiléster (C1-C12) alquilencarboxílico (C1-C12); cada R2 es, de manera independiente, alquilo (C1-C12), carbonil-alquilo (C1-C12) o alquiléster (C1-C12) carboxílico; cada R3 es, de manera independ
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