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Tricyclic lactones for cancer treatment
专利权人:
Glactone Pharma Development AB
发明人:
GIDLÖF, Ritha,JOHANSSON, Martin,STERNER, Olov,MUNOZ, Eduardo
申请号:
ES11739028
公开号:
ES2553248T3
申请日:
2011.07.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound according to formula (I) or (II) ** Formula ** in which R1 and R1 'are independently selected from the group consisting of H, C1-5 alkyl, and C0-1-aryl alkylene; R2 and R2 'are independently selected from the group consisting of H, C1-5 alkyl, and C0-1-aryl alkylene; R3 and R3 'are independently selected from the group consisting of H, C1-5 alkyl, and C0-1-aryl alkylene; R4 and R4 'are independently selected from the group consisting of H, C1-5 alkyl, and C0-1-aryl alkylene; R5 is selected from the group consisting of C0-5 O-alkyl, C1-5 O-fluoroalkyl, OC (O) C1-5 alkyl, C2-3N O-alkylene (C0-5 alkyl) 2 in which the C0-5 alkyl may be the same or different, NH-C0-5 alkyl, N (C1-5 alkyl) 2 in which the C1-5 alkyl may be the same or different, N ( C0-5) C (O) C1-5 alkyl, NHaryl, NHheteroaryl, a 3- to 8-membered non-aromatic heterocycle that is connected by a substitutable heteroatom of said non-aromatic heterocycle, S-C0-5 alkyl, S (O) C0-5 alkyl, SO2-C0-5 alkyl, and N (C0-C3 alkyl) SO2-C1-C5 alkyl; R6 is selected from the group consisting of H, C1-5 alkyl, C1-5 fluoroalkyl, and a non-aromatic C3-8 carbocycle; at least one of R2, R2 ', R3, R3', R4 and R4 'comprises a carbon atom; and said heteroaryl is a 5-membered heteroaryl, or a 6-membered heteroaryl; as a free base, an acid in its uncharged protonated form, a pharmaceutically acceptable addition salt, solvate, solvate of a salt thereof, a pure diastereomer, a pure enantiomer, a diastereomeric mixture, a racemic mixture, a chimemic mixture, a corresponding tautomeric form that results from a displacement of hydrogen between two heteroatoms and / or the corresponding tautomeric form that results from a ketoenolic tautomerization.Compuesto según la fórmula (I) o (II)**Fórmula** en el que R1 y R1' se seleccionan independientemente de entre el grupo que consiste en H, alquilo de C1-5, y alquileno de C0-1-arilo; R2 y R2' se seleccionan independientemente de entre el grupo que consiste en H, alquilo de C1-5, y alqu
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