INSTITUTO DE PESQUISAS TECNOLÓGICAS DO ESTADO DE SÃO PAULO S/A
发明人:
AMBROSIO ZANIN, MARIA HELENA,Ambrosio Zanin, Maria Helena,MARIM DE OLIVEIRA, ADRIANO,Marim de Oliveira, Adriano,NETO PEREIRA CERIZE, NATÁLIA,Neto Pereira Cerize, Natália,ALVES DOS SANTOS, VALDIRENE,Al
申请号：
BRBR2013/000527
公开号：
WO2014/089649A1
申请日:
2013.12.02
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The invention pertains to the field of medicinal, odontological and similar products, of oral administration preparations and medicinal preparations containing active ingredients having a therapeutic action, and is characterised by special nanotructured physical forms (nanofibres) that form a nonwoven film or cover that contains active ingredients, these active ingredients being organic compounds that have an antifungal action and are encapsulated into and/or adsorbed into the surface, and are released in a controlled way, increasing the stability of the active substance, modulating its release over time, and acting as a carrier for the ingredients in the oral mucosa. The nanofibre is produced by electrospinning, using polymer materials as the encapsulating matrix and an active ingredient from the group of antimicrobial agents for odontological, pharmaceutical and veterinary application； the encapsulant is composed of various polymers such as polysaccharides, proteins of animal or vegetable origin, chitosan, gums, cellulose derivatives, polyvinylpyrrolidone (PVP), poly(meth)acrylates (PM), poly(meth)acrylamides, polyesters, polyvinyl caprolactams, polyamides, polyvinyl alcohol (PVA) or mixtures of these polymers and other excipients that may be necessary to satisfy market demands； and the active substance can be an antifungal agent for oral applications, preferably cetylpyridinium chloride (CPC), it being possible to combine more than one active substance in the same product. Since the disclosed system has a nanostructure with a suitably controlled morphology and chemical composition, it allows a product to be obtained for the controlled release of active substances, which can be applied directly to the inside of the mouth, which adheres to the oral mucosa and produces a transmucosal active substance release system that can be used to carry active substances of local or systemic application.L'invention, intitulée "Nanofibres contenant une substance active à libérati
