INSTITUTO DE PESQUISAS TECNOLOGICAS DO EST S. PAULO S/A IPT
发明人:
MARIA HELENA AMBROSIO ZANIN,ADRIANO MARIM DE OLIVEIRA,NATALIA NETO PEREIRA CERIZE,VALDIRENE ALVES DOS SANTOS
申请号：
BR102012031955
公开号：
BR102012031955A2
申请日:
2012.12.14
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
NANOFIBRAS CONTAINING ACTIVE SUBSTANCE WITH CONTROLLED RELEASE FOR DONTOLOGICAL APPLICATION AND PROCESS, belonging to the medical, dental and similar products sector, oral administration preparations and medicinal preparations containing therapeutic active ingredients are nanostructured physical forms (nanofibers) forming film or Non-woven blanket containing active ingredients in its interior, these active ingredients being organic compounds of antifungal action that are encapsulated and / or adsorbed on the surface, and are released in a controlled manner, providing stability to the active, modulating its release over time and acting on the surface. delivery of ingredients in the oral mucosa. Nanofiber is obtained by the electrofinning process, employing polymeric materials as encapsulating matrix and by an active ingredient of the group of antimicrobials for dental, pharmaceutical and veterinary application； the encapsulant r being composed of different polymers such as polysaccharides, animal or vegetable protein, chitosan, gums, cellulose derivatives, polyvinylpyrrolidone (PVP), poly (meta) acrylates (PM), poly (meta) acrylamides, polyesters, polyvinylcaprolactams, polyamides, polyvinyl alcohol (PVA) or blends of such polymers and other excipients as may be required to serve the market； and the active is antifungal for oral use, preferably cetylpyridinium chloride (PCC), allowing the association of more than one active in the same product. Since the system presented here is a nanostructure with morphology and chemical composition properly controlled, it allows a controlled release of active products capable of being applied directly inside the mouth, adhering to the buccal mucosa and giving rise to a transmucosal active release system. It can be applied in the placement of assets of local or systemic application.NANOFIBRAS CONTENDO SUBSTÂNCIA ATIVA COM LIBERAÇÃO CONTROLADA PARA APLICAÇÃO ODONTOLÓGICA E PROCESSO, pertencente ao setor de produtos médicos, odontoló
