The invention relates to a system, methods and apparatus for efficiently and cost-effectively preventing the transfer of microbes, such as, for example, bacteria and viruses seamlessly during commercial transactions typically occurring at a full service check-out station in a large retail store. The invention further considers the application of the methods and apparatus in other industrial disciplines where, for example, medical equipment and surgical tools may be susceptible to cross-contamination of microbes. One preferred embodiment incorporates a slidable drawer within a cash box where currency is stored, taken, or added randomly over a period of time. Especially designed lamps allow for a rapid switching means to control the time period for activating or deactivating lamps, thus regulating UV exposure. Exposure time with UVC and the orientation of the UV lamps provides complete germicidal decontamination within seconds.