It is provided a production process (1) for compounds having hypotensive activity adapted to be used for preparing foods, drinks and dietary supplements said production process (1) being adapted to obtain compounds having hypotensive activity (10) from processing/working of Lupinus seeds (11) and comprising an extraction step (3) in which a protein solution (13) is obtained from the seeds and a hydrolysis step (4) in which the proteins of the protein solution (13) are fragmented thus obtaining the compounds having hypotensive activity (10), which consist of peptides of a molecular weight lower than 3000 Da and having an aromatic or hydrophobic amino acid as the terminal group so as to determine an IC50 lower than 1000 µg/mL.