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INHIBITEURS DE NEPRILYSINE DONNEURS D'OXYDE NITRIQUE
专利权人:
THERAVANCE BIOPHARMA R&D IP; LLC
发明人:
MAMMEN, MATHAI,HUGHES, ADAM
申请号:
CA2871292
公开号:
CA2871292A1
申请日:
2013.05.30
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
In one aspect, the invention relates to compounds having the formula: (I) where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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