PROBLEM TO BE SOLVED: To provide an ATP production promoter capable of activating an ATP synthetic enzyme by directly acting on the enzyme and to provide an agent containing the ATP production promoter and preventing and/or treating ischemic disease.SOLUTION: There is provided an ATP production promoter containing (1) a G0s2 protein or a pharmaceutically acceptable salt thereof, or (2) a DNA encoding the protein described above (1) as an active ingredient.COPYRIGHT: (C)2014,JPO&INPIT【課題】ATP産生酵素に直接作用して該酵素を活性化させることができるATP産生促進剤、及び該ATP産生促進剤を含有する虚血性疾患の予防及び/又は治療剤等を提供する。【解決手段】(1)G0s2タンパク質又はその薬学的に許容される塩、又は(2)前記(1)に記載のタンパク質をコードするDNAを有効成分として含むATP産生促進剤。【選択図】なし