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TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
专利权人:
发明人:
David Spiegel,Kelly Fitzgerald
申请号:
US15374272
公开号:
US10016412B2
申请日:
2016.12.09
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
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