KIM, Hong-Kee,김홍기,SHIN, Ho Chul,신호철,OH, Joon-gyo,오준교,LEE, Kyu Ho,이규호,KIM, Hun-Taek,김훈택
申请号：
KRKR2013/010506
公开号：
WO2014/077655A1
申请日:
2013.11.19
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to a sustained-release polymer microsphere containing anastrozole, and more specifically, to a method for preparing a sustained-release polymer microsphere containing anastrozole, a polymer microsphere prepared thereby, and a pharmaceutical composition comprising same, wherein in the method for preparing the sustained-release polymer microsphere containing anastrozole includes a method for preparing polymer particulates by dissolving a polymer compound and anastrozole in a solvent, coagulating same into particulates, and then processing the coagulated polymer particulates with an alcohol aqueous solution, so that the ratio of a maximum serum concentration (Cmax) with respect to an average serum concentration of anastrozole (Cave) during release is between 1 to 20. A method for preparing a sustained-release polymer particulate containing anastrozole, according to the present invention, enables preparation of the polymer particulate for lowering the ratio of a maximum serum concentration (Cmax) with respect to an average serum concentration of anastrozole (Cave) during release to 1 to 20, and thus can be effectively used for preparing a sustained-release pharmaceutical composition having continuous release properties for treating cancer.La présente invention concerne une microsphère polymère à libération prolongée contenant de lanastrozole, et plus spécifiquement, un procédé de préparation dune microsphère polymère à libération prolongée contenant de lanastrozole, une microsphère polymère ainsi préparée, et une composition pharmaceutique comprenant celle-ci, lequel procédé de préparation de ladite microsphère polymère à libération prolongée contenant de lanastrozole comprend un procédé de préparation dune matière particulaire polymère par dissolution dun composé polymère et danastrozole dans un solvant, la coagulation de ceux-ci sous forme de matière particulaire, puis le traitement de la matière particulaire polymère coagulée avec une so
