CHOI, Youn-Woong,최연웅,CHO, Sang Min,조상민,MIN, Byung Gu,민병구,PARK, Jin Ha,박진하,KIM, Bo Kyung,김보경
申请号：
KRKR2012/003223
公开号：
WO2012/148181A2
申请日:
2012.04.26
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a composition for the controlled-release of drugs. More particularly, the composition for the controlled-release of drugs according to the present invention expands the capacity for the controlled-release of a matrix-type polymer for controlled-release via a carbomer in which said polymer for controlled-release forms a basic frame and in which sol-gel transition occurs in accordance with a pH level. The composition of the present invention is characterized in that it comprises: a solubilizing agent for the event the drug to be released is highly insoluble, and a disintegrating agent for sufficient initial release. The composition for the controlled-release of drugs according to the present invention uses a carbomer which maintains the controlled-release of conventional matrix structures having polymers for controlled-release and which has sol-gel transition properties, thus preventing a sudden release of a drug caused by a collapse of the matrix structure during a late stage of elution. In addition, the composition of the present invention uses a solubilizing agent to solve the problem of a highly insoluble drug failing to dissolve even after being released, and also uses a disintegrating agent to improve the speed of the initial release, which is the limiting factor in controlled-release preparations.La présente invention concerne une composition à libération contrôlée de médicaments. Plus particulièrement, la composition à libération contrôlée de médicaments selon la présente invention permet détendre la capacité de libération contrôlée dun polymère de type matrice à une libération contrôlée par le biais dun carbomère, ledit polymère à libération contrôlée formant une structure basique et une transition sol-gel ayant lieu selon la valeur du pH. La composition de la présente invention est caractérisée en ce quelle comprend : un agent solubilisant dans le cas où le médicament à libérer est très peu soluble, et un agent délitant desti
