Compositions and methods for manipulation of adipocyte energy consumption regulatory pathway

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专利权人:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY;EUROPEAN MOLECULAR BIOLOGY LABORATORY

发明人:

Manolis Kellis,Melina Christine Claussnitzer,Jan Korbel

申请号：

US15539621

公开号：

US10774326B2

申请日:

2015.12.23

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.

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