COMPOSITIONS AND METHODS FOR MANIPULATION OF ADIPOCYTE ENERGY CONSUMPTION REGULATORY PATHWAY

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专利权人:

Massachusetts Institute of Technology

发明人:

KELLIS, Manolis,CLAUSSNITZER, Melina, Christine,KORBEL, Jan

申请号：

EP15873805

公开号：

EP3237642A4

申请日:

2015.12.23

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rsl421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.

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