CIANCHETTA, Giovanni,DELABARRE, Byron,POPOVICI-MULLER, Janeta,SALITURO, Francesco G.,SAUNDERS, Jeffrey O.,TRAVINS, Jeremy M.,YAN, Shunqi,GUO, Tao,ZHANG, Li
申请号：
ES13733752
公开号：
ES2675760T3
申请日:
2013.01.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having Formula I or a pharmaceutically acceptable salt or hydrate thereof: wherein: ring A is a substituted monocyclic heteroaryl optionally selected from oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, pyrazinyl and thiazolyl, wherein ring A is substituted optionally with up to two substituents independently selected from halo, -C1-C4 alkyl, halo -C1-C4, hydroxyalkyl-C1-C4, -NH-S (O) 2- (C1-C4 alkyl), -S (O) 2NH (C1-C4 alkyl), -CN, -S (O) 2- (C1-C4 alkyl), C1-C4 alkoxy, -NH (C1-C4 alkyl), -OH, -OCF3, -CN, -NH2, -C (O) NH2, -C (O) NH (C1-C4 alkyl), -C (O) -N (C1-C4 alkyl) 2, and cyclopropyl optionally substituted with OH； Ring B is an optionally substituted monocyclic monocyclic aryl or heteroaryl； R1 and R3 are each independently selected from hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, -O-C1-C4 alkyl and CN, wherein any alkyl portion of R1 is optionally substituted with -OH, NH2, NH (C1-C4 alkyl) or N (C1-C4 alkyl) 2； R2 is selected from: - (C1-C6 alkyl), - (C2-C6 alkenyl or alkynyl), - (C1-C6 alkylene) -N (R6) - (C1-C6 alkylene) -O- (C1-C6 alkyl ), - (C1-C6 alkylene) -N (R6) - (C0-C6 alkylene) -Q, - (C1-C6 alkylene) -N (R6) (R6), - (C1-C6 alkylene) -N ( R6) -S (O) 1-2- (C1-C6 alkyl), - (C1-C6 alkylene) -N (R6) -S (O) 1-2- (C0-C6 alkyl) -Q, - ( C1-C6 alkylene) - S (O) 1-2-N (R6) (R6), - (C1-C4 alkylene) -S (O) 1-2-N (R6) - (C1-C6 alkylene) - Q, -C (O) N (R6) - (C1-C6 alkylene) -C (O) - (C0-C6 alkylene) -O- (C1-C6 alkyl), -C (O) N (R6) - (C1-C6 alkylene) -C (O) - (C0-C6 alkylene) -O- (C0-C6 alkylene) -Q, - (C1-C6 alkylene) -OC (O) - (C1-C6 alkyl), - (C1-C6 alkylene) -OC (O) - (C0-C6 alkyl) -Q, - (C1-20 C6 alkylene) -O- (C1-C6 alkyl), - (C1-C6 alkylene) -O- (C1-C6 alkylene) -Q, - (C0-C6 alkylene) -C (O) - (C0-C6 alkylene) -O- (C1-C6 alkyl), - (C0-C6 alkylene) -C (O) - (C0-C6 alkylene) -O- (C1-C6 alkylene) -Q, - (C1-C6 alkylene) -OC (O) - (C1-C6 alkyl), - (C1-C6 alkylene) -OC (O ) - (C0-C6 alkylene) -Q, - (C0-C6 alkylene) -C (O) N (R6) - (C1-C6 alkyl), - (alkyl
