Tregear, Geoffrey W.,Bathgate, Ross Alexander David,Hossain, Mohammed Akhter,Wade, John Desmond,Samuel, Chrishan Surendran
申请号：
AU2008318278
公开号：
AU2008318278B2
申请日:
2008.10.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Modified relaxin polypeptides are disclosed wherein the B chain comprises thecore sequence CGRxxxRxxI/VxxCG (SEQ ID NO: 1), specifically KLCGRELVRAQIAIC.Chimeric polypeptides comprising a B chain with the core sequence CGRxxxRxxFVxxCG(SEQ ID NO: 1) and an A chain from a heterologous relaxin family peptide are alsodisclosed. Specifically, chimeric polypeptides comprising a B chain from relaxin-2,and an A chain from relaxin- 1, relaxin-3, insulin, IGF-I, IGF-II, INSL3, INSL4,INSL5 or INSL6, are disclosed.
