Jonathan Lewis Telfer;Mark Richard Redfern;Michael Joseph Lacy
发明人:
Jonathan Lewis Telfer,Mark Richard Redfern,Michael Joseph Lacy
申请号：
US12999246
公开号：
US08703153B2
申请日:
2009.06.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides an attenuated Salmonella vaccine vector comprising one or more heterologous polynucleotides that encode immunogenic Chlamydial peptides. In one embodiment, the attenuated Salmonella vaccine vector comprises aroC and ssaV attenuating mutations. The heterologous polynucleotides encoding the immunogenic Chlamydial peptides can be under the control of an inducible promoter such as a Salmonella ssaG promoter. In one embodiment of the invention, the immunogenic Chlamydial peptide is a PmpG peptide, for instance, a CT110, CT84 or CT40 peptide.
