MENET CHRISTEL JEANNE MARIE,VATER HUW DAVID,HODGES ALASTAIR JAMES
申请号：
ZA201307793
公开号：
ZA201307793B
申请日:
2013.10.18
申请国别(地区):
ZA
年份:
2015
代理人:
摘要：
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolites thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant JAK activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
