Water soluble membrane proteins and methods for the preparation and use thereof

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专利权人:

Massachusetts Institute of Technology

发明人:

Shuguang Zhang,Alexander Rich,Karolina Corin,Lotta Tolstoy Tegler

申请号：

US15078036

公开号：

US10035837B2

申请日:

2016.03.23

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing residues leucine (L), isoleucine (I), valine (V), and phenylalanine (F) in hydrophilic surface α-helical positions b, c, and f but not positions a, d, e, and g within the 7-transmembrane α-helical domain of the GPCR with glutamine (Q), threonine (T), threonine (T), and tyrosine (Y), respectively.

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