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METHOD FOR PRODUCING GRANULES CONTAINING AN ACTIVE INGREDIENT, HAVING AN OPTIMISED BEST-BEFORE DATE AND ACTIVE INGREDIENT LOAD
专利权人:
EXPRESSIONS AROMATIQUES
发明人:
Vincent Carpentier,Benedicte Ravel
申请号:
US14888299
公开号:
US20160058046A1
申请日:
2014.06.20
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A method for producing granules that contain at least one active ingredient and are stable at ambient temperature, includes successively: (1) preparing a matrix free of an active ingredient by mixing, without the addition of water, an encapsulation vehicle for the active ingredient and a non-aqueous plasticiser compatible with the vehicle and the active ingredient, the encapsulation vehicle and the plasticiser being present in amounts that give the matrix a glass transition temperature higher than the ambient temperature; (2) heating the matrix in an extruder to an extrusion temperature to produce an amorphous melt matrix; (3) injecting the active ingredient into the melt matrix; (4) extruding the melt mass including the active ingredient through a die and cutting granules at an exit point of the die.
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