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UN PROCÉDÉ NOUVEAU POUR LA PRÉPARATION DE LA BOSENTAN.
专利权人:
Megafine Pharma (P) Ltd.
发明人:
申请号:
EP11726502.5
公开号:
EP2603497B1
申请日:
2011.03.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A novel ammonium salt of Bosentan of formula (VIII); has been disclosed. The salt may be either crystalline or amorphous or mixture of Crystalline and amorphous form. A novel single pot process for the preparations of ammonium salt of Bosentan has been disclosed. The process comprises reacting the 4,6-dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine with 4-tert-butylbenzenesulfonamide in the presence of solvent and a base; adding ethylene glycol to the reaction mass and isolating the ammonium salt of Bosentan. The ammonium salt of Bosentan is converted into Bosentan and further into Bosentan Monohydrate which are substantially free from dimer impurity and 6-hydroxy impurity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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