PD1/CTLA4 BINDERS农业专利-农业学术服务平台

发明人:: PUNNONEN, JUHA,普农诺朱哈,普農諾朱哈,BOWMAN, EDWARD,柏曼艾德华,柏曼艾德華,BEAUMONT, MARIBEL,毕蒙特玛力柏,畢蒙特瑪力柏,BUYSE, MARIE-ANGE,拜司玛丽-安己,拜司瑪麗-安己,BOUTTON, CARLO,巴顿卡罗,巴頓卡羅,DOMBRECHT, BRUNO,东布奇布鲁诺,東布奇布魯諾,VICTOR, BJOR

摘要：: The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.本發明提供結合至PD1及CTLA4之多特異性分子,例如包含多於一種ISVD或奈米抗體。此等分子已經工程改造以減少投與此分子之個體身體中預先存在抗體之結合發生。提供用此分子增加免疫反應、治療癌症及/或治療感染性疾病之方法。