Buprenorphine analogs as agonists and / or opioid receptor antagonists

• 收藏
• 分享

专利权人:

Purdue Pharma L.P.

发明人:

KYLE, Donald J.,TAFESSE, Laykea

申请号：

ES11776855

公开号：

ES2566828T3

申请日:

2011.09.20

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

A compound of Formula I: ** Formula ** in which R1 is selected from hydrogen, -alkyl- (C1-C10), alkenyl- (C2-C12), alkynyl- (C2-C12), alkoxy- (C1- C10), cycloalkyl- (C3-C12), (cycloalkyl (C3-C12)) - alkyl- (C1-C6), heteroaryl- (5 to 12 members) and (heteroaryl (10 to 12 members)) - alkyl - (C1-C6)； any of which is optionally substituted with 1, 2, or 3 substituents that are independently selected from the group consisting of alkyl- (C1-C6), -COOR7 and -CONR9R10； R2 and R8 are each independently hydrogen, alkyl- (C1-C10), alkynyl- (C2-C12), alkoxy- (C1-C10), - (OCH2CH2) s-Oalkyl (C1-C6), - (CH2CH2O) s-(C1-C6) alkyl, -NH2, -NH (C1-C6) alkyl, -CONR5R6, alkyl- (C1-C6) -CO-NR5R6, -COOR7, alkyl- (C1-C6) -CO-OR7, cycloalkyl- (C3-C12), aryl- (5 to 12 members), (aryl (5 to 12 members)) - alkyl- (C1-C6), heteroaryl- (5 to 12 members), bicycloheterocycle- ( 7 to 12 members), phenyl, benzyl or naphthyl； each of which is optionally substituted with one or two substituents that are independently selected from the group consisting of -OH, halo, -C (halo) 3, -CH (halo) 2, - CH2 (halo), alkyl- ( C1-C6), alkenyl- (C2-C6), alkynyl- (C2-C6), hydroxyalkyl- (C1-C6), dihydroxyalkyl- (C1-C6), alkoxy- (C1-C6), (alkoxy (C1- C6)) CO-C1-C6 alkoxy, phenyl, benzyl, -NH2, -CN, -OR4, -CONR5R6, - (C1-C6 alkyl) -CO-NR5R6, -COOR7, alkyl- (C1-C6) - CO-OR7, alkoxy- (C1-C6) -COOR7, - (OCH2CH2) s-Oalkyl (C1-C6), -NH-SO2alkyl (C1-C6), -N (SO2alkyl (C1-C6)) 2, - C (>； = NH) NH2, -NH-CO-(C1-C6) alkyl, -NH-CO-NH2, - NH-C (>； = O) -NH-(C1-C6) alkyl, -NH-C (>； = O) aryl- (5 to 12 members), -NH-(C1-C6) alkyl -CO-OR7, -NH-C (>； = O) - (C1-C6) alkyl -CO-OR7, aryl- (5 to 12 members), -NH-(C1-C6) alkyl -C (O) -NR5R6, -C (O) NH-alkyl (C1-C6) - COOR7, heteroaryl- (5 to 12 members) and (heteroaryl (5 to 12 members)) - (C1-C6) alkyl -； wherein at least one of R2 and R8 is alkyl- (C1-C10), alkynyl- (C2-C12), alkoxy- (C1-C10), - (OCH2CH2) s- Oalkyl (C1-C6), - ( CH2CH2O) s-(C1-C6) alkyl, NH2, -NH (C1-C6) alkyl, -C

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/