FIELD: pharmacology.SUBSTANCE: invention relates to a compound of the formula (I), where R1 and R2 together form -CR14=CR15-CR16=CR17-, -CR14R15-O-(CR16R17)m-CR18R19-, -CR14R15-(CR16R17)m-O-CR18R19-, -O-CR14R15-(CR16R17)m-CR18R19-, -CR14R15-NR22-CR16R17-CR18R19-, -CR14R15-S(O)2-CR16R17-CR18R19-, -CR14R15-CR20R21- or -CR14R15-CR16R17- (CR18R19)p-CR20R21-； R3 is phenyl or substituted 5-6 membered heteroaryl with one to three ring heteroatoms selected from N, O and S, wherein the substituted heteroaryl is substituted by R23； R4 is H； R5 and R6 are independently selected from H and alkyl； R7 is H or alkyl； A is NR8 or CR9R10； E is NR11 or CR12R13； R9, R10, R12 and R13 are independently selected from H, a halogen atom and alkyl； or R8 and R12 together with the nitrogen and carbon atoms to which they are attached, form a substituted 4-6 membered heterocycloalkyl with one nitrogen atom as a ring heteroatom, wherein the substituted heterocycloalkyl is substituted by R26； or R9 and R11 together with the nitrogen and carbon atoms to which they are attached, form a substituted 5-membered heterocycloalkyl with one nitrogen atom as a ring heteroatom； or R9 and R12 together with the carbon atoms to which they are attached, form a substituted 3-8 membered saturated or unsaturated cycloalkyl, substituted phenyl, substituted 6-membered heterocycloalkyl with one oxygen atom as a ring heteroatom or substituted 5-6 membered heteroaryl with one to two nitrogen atoms as ring heteroatoms, wherein the substituted cycloalkyl, substituted phenyl, substituted heterocycloalkyl and substituted heteroaryl are substituted by R26 and can be further substituted by R27, where in case when R9 and R12 together with the carbon atoms to which they are attached, form substituted phenyl or substituted heteroaryl, R10 and R13 are absent； or R10 and R13 together with the carbon atoms to which they are attached form a double bond； R14, R15, R16, R17, R18, R19, R20, R21, R23, R24, R25, R26 and R27 are indepe
