YEN, LIN JU,颜伶汝,顏伶汝,LIU, KO JIUNN,刘柯俊,劉柯俊,SYTWU, HUEY KANG,司徒惠康
申请号：
TW104127973
公开号：
TW201628642A
申请日:
2015.08.26
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present application provides a method of upregulating an expression of immumodulatory cells in vitro comprising treating the immumodulatory cells with IL-25 to increase an expression of PD-L1. The present application also provides a method for treatment of immune disorders by the aforementioned methods. The present application also provides a method to suppress an expression of immumodulatory cells comprising suppressing an expression of PD-L1. The immumodulatory cells can be human monocytes or hMSCs. The present application further provides a method for treatment of immune-evasive diseases by using the aforementioned method to suppress an expression of immumodulatory cells.本發明係提供一種於體外提升免疫調節細胞之表現之方法，係包括以IL-25處理該免疫調節細胞以增加PD-L1之表現。本發明亦提供一種藉由前述方法治療免疫異常之方法。本發明亦提供一種抑制免疫調節細胞表現之方法，係包括抑制PD-L1之表現。該免疫調節細胞可為人類單核細胞或人類間葉幹細胞。本發明亦提供一種藉由前述方法抑制免疫調節細胞表現而治療免疫功能缺陷相關疾病之方法。
