Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.本文揭示載體,其包括抗原編碼核酸序列及共表現免疫調節因子。亦揭示與該等載體相關之核苷酸、細胞及方法,包括該等載體作為疫苗之用途。