Supramolecular complexes as photoactivated DNA cleavage agents

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专利权人:

Karen Brewer

发明人:

Karen Brewer,Shawn Swavey

申请号：

US12610729

公开号：

US08445475B2

申请日:

2009.11.02

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

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