Jana Paetz,Daniela Stumm,Wolfgang Albrecht,Alexandre Mathieu
申请号：
US13695433
公开号：
US20130116333A1
申请日:
2011.05.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to solid tapentadol in non-crystalline form together with a surface stabiliser in the form of a stable intermediate. In the intermediate of the invention, tapentadol is preferably present in amorphous form or in the form of a solid solution. The invention further relates to methods of producing tapentadol in a solid, non-crystalline form and to pharmaceutical formulations containing solid, non-crystalline tapentadol.
