SOLID FORMS OF ORTATAXEL

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专利权人:

INDENA S.P.A.

发明人:

CICERI, DANIELE,SARDONE, NICOLA,GABETTA, BRUNO,RICOTTI, MAURIZIO

申请号：

HK09110647.7

公开号：

HK1131782B

申请日:

2009.11.13

申请国别(地区):

HK

年份:

2013

代理人:

摘要：

The present invention relates to solid forms of 13-(N-Boc-β-isobutylserinyl)-14-β-hydroxybaccatin III 1,14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.

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