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Perforin-2 activators and inhibitors as drug targets for infectious disease and gut inflammation
专利权人:
University of Miami
发明人:
Podack, Eckhard,McCormack, Ryan
申请号:
AU2014331938
公开号:
AU2014331938A1
申请日:
2014.10.08
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
Methods and compositions are provided to modulate the activity of Perforin-2. Provided herein are various components of the Perforin-2 activation pathway. In specific embodiments, inhibitors of the various components of the Perforin-2 activation pathway are provided which may be employed in various methods, including, but not limited to, the diagnosis and treatment of diseases associated with gut inflammation. Methods of screening for Perforin-2 inhibitors are also provided. Further provided are compounds that increase the ubiquitination of Perforin-2 and thereby increase Perforin-2 activity. Various methods for increasing Perforin-2 activity and for the treatment of infectious disease, in particular bacteria and antibiotic-resistant bacteria, are also provided.
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