WANG, Tao,KADOW, John F.,MEANWELL, Nicholas A.,ZHANG, Zhongxing,YIN, Zhiwei,RUEDIGER, Edward H.,JAMES, Clint A.,DEON, Daniel H.
申请号：
ES13748451
公开号：
ES2616432T3
申请日:
2013.08.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I, including pharmaceutically acceptable salts thereof: ** Formula ** in which A is selected from the group consisting of: ** Formula ** and in which a, b, c, d and d are selected independently among the group consisting of hydrogen, halogen, cyano, nitro, COOR56, XR57, NA1A2, C (O) R7, C (O) NR55R56, B, Q and E； B is selected from the group consisting of -C (>； = NR46) (R47), C (O) NR40R41, aryl, heteroaryl, heteroalicyclic, S (O) 2R8, S (O) 2NR40R41, C (O) R7, XR8a, (C1-6) alkyl -NR40R41, (C1-6) alkyl -COOR8b； wherein said aryl, heteroaryl and heteroalicyclic are optionally substituted with one to three same or different halogens or one to three same or different substituents selected from the group F； wherein aryl is naphthyl or substituted phenyl； wherein heteroaryl is a mono or bicyclic system containing from 3 to 7 ring atoms for a monocyclic system and up to 12 atoms in a condensed bicyclic system, including 1 to 4 heteroatoms； wherein the heteroalicyclic is a 3- to 7-membered cyclic mono ring that may contain 1 to 2 heteroatoms in the main chain of the ring and that may be fused to a benzene or pyridine ring； Q is selected from the group consisting of (C1-6) alkyl, (C3-7) cycloalkyl and (C2-6) alkenyl； wherein said (C1-6) alkyl and (C2-6) alkenyl are optionally substituted with one to three same or different halogens or one to three same or different substituents selected from the group consisting of C (O) NR55R56, hydroxy, cyano and XR57； E is selected from the group consisting of (C1-6) alkyl, (C3-7) cycloalkyl and (C2-6) alkenyl； wherein said (C1-6) alkyl and (C2-6) alkenyl are, independently, optionally substituted with a member selected from the group consisting of phenyl, heteroaryl, SMe, SPh, -C (O) NR56R57, C ( O) R57, SO2-C1-6 alkyl and SO2Ph； wherein heteroaryl is a monocyclic system that contains 3 to 7 ring atoms, including 1 to 4 heteroatoms； F is selected from the group consisting of (C1-6) alkyl, (C3-7) cycloalkyl, aryl
