WANG, Tao,ZHANG, Zhongxing,KADOW, John F.,MEANWELL, Nicholas A.
申请号：
ES12766362
公开号：
ES2616268T3
申请日:
2012.08.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of Formula I, including pharmaceutically acceptable salts thereof: ** ** Formula wherein A is selected from the group consisting of: ** ** Formula in which a, b, c, d and e are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, COOR56, XR57, NA1A2, C (O) R7, C (O) NR55R56, B, Q, and E； B is selected from the group consisting of -C (>； = NR46) (R47), C (O) NR40R41, aryl, heteroaryl, heteroalicyclic, S (O) 2R8, S (O) 2NR40R41, C (O) R7, XR8a, (1-6C) NR40R41, (1-6C) COOR8b； wherein said aryl, heteroaryl, and heteroalicyclic are optionally substituted with one to three same or different halogens or from one to three same or different substituents selected from the group F； wherein aryl is naphthyl or substituted phenyl； wherein heteroaryl is a mono or bicyclic system which contains from 3 to 7 ring atoms for a monocyclic system and up to 12 atoms in a fused bicyclic system, including from 1 to 4 heteroatoms； wherein heteroalicyclic is a monocyclic ring of 3 to 7 members which may contain from 1 to 2 heteroatoms in the ring skeleton and which may be condensed with a benzene ring or pyridine； Q is selected from the group consisting of (1-6C) alkyl and (2-6C) alkenyl； wherein said (C1-6) alkyl and (2-6C) alkenyl are optionally substituted with one to three same or different halogens or from one to three same or different substituents selected from the group consisting of C (O) NR55R56 , hydroxy, cyano and XR57； E is selected from the group consisting of (1-6C) alkyl and (2-6C) alkenyl； wherein said (C1-6) alkyl and (2-6C) alkenyl are independently optionally substituted with a member selected from the group consisting of phenyl, heteroaryl, SMe, SPh, -C (O) NR56R57, C (O ) R57, SO 2 (1-6C) alkyl and SO2Ph； wherein heteroaryl is a monocyclic system which contains from 3 to 7 ring atoms, including 1 to 4 heteroatoms； F is selected from the group consisting of (1-6C) alkyl, (C3-7) alkyl, aryl, heteroaryl, heteroalicyclic, hydroxy,
