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Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
专利权人:
Tatsushi Yokogawa;Wakako Yano;Seiji Miyahara;Hitoshi Miyakoshi;Junko Taguchi;Yayoi Takao;Masayoshi Fukuoka
发明人:
Masayoshi Fukuoka,Tatsushi Yokogawa,Seiji Miyahara,Hitoshi Miyakoshi,Wakako Yano,Junko Taguchi,Yayoi Takao
申请号:
US12996079
公开号:
US08530490B2
申请日:
2009.06.02
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug.A uracil compound represented by the general formula (I) or a salt thereof:wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.
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