C.N.C.C.S. SCARL COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING;IRBM—SCIENCE PARK S.P.A.
发明人:
Sergio Altamura,Ilaria Biancofiore,Alberto Bresciani,Federica Ferrigno,Steven Harper,Ralph Laufer,Jesus Maria Ontoria Ontoria,Savina Malancona,Edith Monteagudo,Emanuela Nizi,Maria Vittoria Orsale,Simo
申请号：
US14437890
公开号：
US09365541B2
申请日:
2013.10.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.
