Gunnar Grue-Sørensen;Anthony Murray;Erik Rytter Ottosen;Tina Dahlerup Poulsen;Simon Feldbæk Nielsen;Søren Christian Schou;Carsten Ryttersgaard;Daniel Rodriguez Greve
发明人:
Simon Feldbæk Nielsen,Daniel Rodriguez Greve,Carsten Ryttersgaard,Gunnar Grue-Sørensen,Erik Rytter Ottosen,Tina Dahlerup Poulsen,Søren Christian Schou,Anthony Murray
申请号：
US13382665
公开号：
US09346809B2
申请日:
2010.07.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to compounds of general formula (I) wherein A, R1, R2, R3, R4, R5, R9, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immunosuppression would be desirable for example in organ transplantation.
