The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the integrin activated pathway and one other angiogenic factor-activated pathway, the compositions of these fusion proteins, as well as methods for producing and using the same.本發明係關於一種抑制血管新生(angiogenesis)之生物製劑(biologic)。特別是,本發明係關於融合蛋白,該融合蛋白可抑制整合蛋白活化路徑(integrin activated pathway)及一其他之血管新生因子活化路徑(angiogenic factor-activated pathway);且關於該等融合蛋白之組合物;以及其製備及使用方法。