Joanne PEACH;David HARDY;Raphael Jean Joel GENEY;Nicholas John PALMER;Graham Peter JONES;Kevin James DOYLE;Christel Jeanne Marie MENET;Benoit Antoine SCHMITT;James Edward Stewart DUFFY
发明人:
Christel Jeanne Marie MENET,Benoit Antoine SCHMITT,Raphael Jean Joel GENEY,Kevin James DOYLE,Joanne PEACH,Nicholas John PALMER,Graham Peter JONES,David HARDY,James Edward Stewart DUFFY
申请号：
US13762155
公开号：
US20130217664A1
申请日:
2013.02.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein.
