Kyeong Soo Kim,Dong Ho Kim,Taek Kwan Kwon,Yong Il Kim,Jae Hyun Park,Jong Soo Woo
申请号：
US14391111
公开号：
US20150098992A1
申请日:
2013.04.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided is a composite formulation comprising multi-unit spheroidal tablets (MUSTs) encapsulated in a hard capsule and a method for preparing same. The inventive hard capsule composite formulation can effectively charge the MUSTs in the limited space of the capsule, which allows charging a high dose of different pharmaceutically active ingredients in a capsule with a relatively small size, to thereby increase the productivity and render it readily administered to patients. Also, the capsule has a good dissolution rate because the pharmaceutically active ingredients contained in the capsule are separated from one another； therefore, the dissolution rates of the ingredients are less affected by one another. It may also be possible to maximize the therapeutic effects of the pharmaceutically active ingredients since the composite formulation has good stability.
