KIM, JU SUNG,김주성,KIM, MYOUNG SU,김명수,JEONG, EUN JI,정은지,KIM, SEOK IN,김석인,JOO, SO KYOUNG,주소경,JUNG, KI HOON,정기훈,KIM, DO YOUNG,김도영,KIM, WAN JOO,김완주
申请号：
KR1020110085901
公开号：
KR1020130022896A
申请日:
2011.08.26
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: An oseltamivir derivative is provided to strongly coupled to a neuraminidase and coupling stability, thereby suppressing the activity of a neuraminidase enzyme and being used as an antivirus agent.CONSTITUTION: An oseltamivir derivative is indicated in chemical formula 1. In chemical formula 1, R1 is N3 or NH2, and R2 is O or S. R3 is a C1-8 linear, a cyclic alkyl group, or a halogen substituent thereof a 5-membered carbon ring a 5-membered heterocyclic group containing O, N, and, S an unsubstituted aryl group or halogen an aryl group which is substituted by OH group, NO2 group, NH2 group, or COOH group phenyl or a phenyl which is substituted by one to three substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy, phenyl, amino, and trifluoromethyl.COPYRIGHT KIPO 2013본 발명에서는 신규한 구조를 갖는 오셀타미비르 유도체 및 그 제조방법이 제공된다. 본 발명에 따른 신규한 구조를 갖는 오셀타미비르 우레아 (또는 티오우레아) 유도체는 우수한 뉴라미니다제 결합(억제) 활성을 나타내어 항바이러스제로 사용될 수 있다.
