A compound having the chemical structure of formula III ** Formula ** or a salt, tautomer or stereoisomer thereof, wherein: L4 is -CH2-, -CH2CH2-, -CH (R40) -, -C (O) - or -C (O) NH-； R81 is chlorine； R82 is selected from the group consisting of hydrogen, C1-3alkyl, C2-3alkyl substituted with fluorine, OH, C1-3alkoxy and C1-3alkoxy substituted with fluorine； R83 is heterocycloalkyl, heteroaryl, or ** Formula ** in which it indicates the point of attachment of R83 to L4 of formula III in which heterocycloalkyl or heteroaryl are optionally substituted with one or more substituents selected from the group consisting of halogen, C1 alkyl -6, C 1-6 alkyl substituted with fluorine, cycloalkylamino, -NHR41, -NR41R41, -OR41 and -S (O) 2R41； R92, R93, R94, R95 and R96 are independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, fluorinated substituted C1-6 alkyl, cycloalkylamino, -NHS (O) 2R41, -NHC (O) R41, -NHR41, -NR41R41, -OR41 and -S (O) 2R41； R40 is selected from the group consisting of C1-6 alkyl and C1-6 alkyl substituted with fluorine； R41 at each occurrence is independently selected from the group consisting of C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein C1-6 alkyl is optionally substituted with one or more substituents selected from the group consisting of fluorine, C1- alkoxy 6, fluorine substituted C1-6 alkoxy, C1-6 alkylthio, fluorinated C1-6 alkylthio, mono-alkylamino, di-alkylamino, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, and in which cycloalkyl, heterocycloalkyl, aryl and heteroaryl such as R41 25 or as C1-6 alkyl substituents are optionally substituted with one or more substituents selected from the group consisting of -OH, -NH2, -CN, -NO2, -S (O) 2NH2, -C (O) NH2, -OR42, -SR42, -NHR42, -NR42R42, -NR39C (O) R42, -NR39S (O) 2R42, -S (O) 2R42, halogen, C1-6 alkyl, fluorinated C1-6 alkyl and cycloalkylamino； and R42 at each occurrence is independently selected from the group consisting of C1-6 alk
