The present invention provides a drug eluting surgical screw and a method of manufacturing a drug eluting surgical screw. The drug eluting surgical screw includes a shaft having a thread; and a head having a drive recess disposed at a proximal end of the shaft, the drive recess having a receiving container area and a driver engagement area. A head; and at least a driver disposed within the container area of the drive recess in a manner that does not substantially impair the connection between the driver and the surgical screw when the driver is operatively disposed within the driver engagement area. One or more drug eluting components, each of the at least one or more drug eluting components comprising a carrier matrix and a therapeutic agent, the therapeutic agent comprising: At least 20% by weight of the drug eluting component prior to any implantation of the drug eluting surgical screw.本発明は、薬物溶出外科用ねじ、及び薬物溶出外科用ねじの製造方法を提供する。この薬物溶出外科用ねじは、ねじ部を有する軸と;この軸の近位末端に配置された駆動凹部を有する頭部であって、この駆動凹部が収容容器領域及びドライバ係合領域を有する、頭部と;ドライバがこのドライバ係合領域内に動作可能に配置された場合、ドライバと外科用ねじとの接続を実質的に損なわない様式で、駆動凹部の収容容器領域内に配置された少なくとも1つ又は2つ以上の薬物溶出構成要素と、を含んでよく、この少なくとも1つ又は2つ以上の薬物溶出構成要素のうちのそれぞれは、担体マトリックス及び治療薬を含み、この治療薬は、薬物溶出外科用ねじの任意の植え込み前に薬物溶出構成要素の少なくとも20重量%である。